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Healing Treatment-Resistant Depression With Psilocybin

Psilocybin is a chemical compound most often associated with “magic mushrooms.” Despite historical stigma, researchers have begun exploring its potential medical applications. This powerful medicine may be especially helpful for clients with treatment-resistant depression (TRD).

This can be an all-consuming diagnosis, and many clients struggle to find effective depression treatment. While some people benefit from tried-and-true medications, like SSRIs and mood stabilizers, these solutions don’t work for everyone. Fortunately, doctors and scientists are actively seeking new ways to treat these clients using experimental modalities. A few options, like ketamine therapy and transcranial magnetic stimulation (TMS),1 are becoming increasingly popular. Psychedelics are also a promising option.

Psychedelic medicine is an increasingly popular treatment2 for a variety of mental health conditions, including depression, anxiety, and PTSD. And a growing body of research supports the theory that psilocybin can be extremely effective in treating TRD.

What Is Psilocybin?

Psilocybin3 is classified as a psychedelic. Substances of this kind “interact with the serotonin receptors (5-HT/5-hydroxytryptamine receptors) and their subtypes densely located within the brain. These receptors mediate emotions and moods such as anxiety and aggression, cognition, sex, learning memory, appetite along with other biological, neurological and neuropsychiatric processes.” The same receptors are also targeted by many pharmaceuticals, including antipsychotics and antidepressants.

Because of its effect on serotonin, scientists are researching psilocybin as a possible treatment for depression, anxiety,4 and a number of other mental health concerns. However, it faces a great deal of social stigma, since it can also be used recreationally. And any recreational substance can be misused. Despite this concern, psychedelics are comparatively safe;5 according to 2013 statistics, LSD and psilocybin combined “accounted for just 0.005 percent of US emergency room visits.”

Psilocybin has not always been legal in the U.S., even for purely scientific purposes. But this is starting to change. As we learn more about its medical applications, it will likely become more accessible to interested clients. As of December, 2021, it has been decriminalized in Denver, Oakland, Santa Cruz, and Detroit. California may soon take this a step further. Senate Bill 519, if passed, would decriminalize psilocybin,6 MDMA, and other psychedelics in the entire state.

Some experts believe this trend will continue. According to one article, despite once being “dismissed as the dangerous dalliances of the counterculture, these drugs are gaining mainstream acceptance. Several states and cities in the United States are in the process of legalizing or decriminalizing psilocybin for therapeutic or recreational purposes.”7

Psilocybin is not considered to be addictive.8 On the contrary, it may even help people recover from substance use disorders. If you think this treatment may be right for you, make sure to use it under medical supervision. Despite its apparent safety, any substance has the potential to be harmful, or to cause relapse.

The Experience of Psilocybin

The word “psychedelic,”3 first used in 1956, comes from the Greek roots “psyche (i.e., the mind or soul) and delos (i.e., to show).” This class of substances can cause visions that reveal a person’s deepest emotional experiences. Using them offers many clients valuable insight into their own mental health.

When taken in larger doses, psilocybin induces a psychedelic “trip,” in which users spend several hours going through an emotional or even spiritual journey. It’s important to undertake this type of experience in a safe and welcoming environment. Research suggests that psilocybin may be especially effective in a natural setting,9 where clients can spend time communing with the great outdoors.

It’s also possible to take psilocybin in smaller amounts, or microdoses. Research has “identified positive associations between microdosing and mental health,10 and…associations between microdosing and reduced severity of symptoms of depression, anxiety and stress among adults with reported mental health concerns.” These experiences can be more accessible, because they are shorter and/or less intense than larger doses. This is a good option for clients who want to improve their mental well-being, but don’t have the emotional capacity to spend several hours experiencing visions.

Mental Health Benefits of Psilocybin

Psychedelics in general, and psilocybin in particular, have a number of known mental health benefits. In one study, “the people who received psilocybin reported significantly more improvements in their general feelings and behavior11 than did the members of the control group. The findings were repeated in another follow-up survey, taken 14 months after the experiment.”

Specifically, research suggests that this medicine may alleviate symptoms of depression,12 suicidality, anxiety, obsessive compulsive disorder, and several types of substance misuse. Subjects have shown “increased ratings of positive attitudes, mood, social effects, and behavior,” even up to 14 months after receiving psilocybin.

For clients with treatment-resistant depression, this is a comparatively safe and low-impact treatment, especially because the controlled use of psilocybin can have such long-term effects. Unlike most medications—like SSRIs—it doesn’t need to be taken daily in order to be effective. This may also make it more accessible to clients who can’t easily afford a regular prescription.

What’s more, psilocybin may be just as effective as these more common treatments. More and more research supports this idea. One study “suggested that psilocybin might work as well as the common antidepressant13 escitalopram (Lexapro) at relieving moderate to severe depression.” Another found that microdoses of psilocybin may cause long-term changes to brain activity,14 causing “increased responses in reward-learning, attention, and decision-making circuits.”

Clients with TRD may also see benefits from this treatment that go beyond relieving their symptoms. For example, experts believe that psilocybin “increases cognitive and neural flexibility in patients with major depressive disorder.”15

Although the data is extremely promising, it’s important to remember that this is a relatively new field of study. Psilocybin is considered to be one of the safer substances available, but it is not entirely without risk.

Potential Risks of Psilocybin

This treatment has some well-known side effects. “About 90% of patients” in one clinical trial “experienced mild to moderate side effects from the psilocybin,16 including nausea, insomnia, fatigue and headache. These symptoms dissipated quickly.” It is most strongly associated with brief gastrointestinal issues. Clients usually experience these symptoms shortly after ingesting psilocybin, and find relief long before the substance wears off.

For certain clients, however, the treatment may cause more dangerous adverse effects. Because psilocybin raises blood pressure,17 “people with uncontrolled hypertension are advised to abstain.” Make sure you talk to your doctor before seeking this treatment, especially if you have a personal or family history of heart problems.

The associated psychological risks may be an even greater concern, especially for clients with certain mental health diagnoses. For example, those with “psychotic disorders such as schizophrenia (or a strong predisposition for them) are generally advised against taking the hallucinogen,” as it may have unpredictable effects, and can even worsen their condition.

And although psilocybin can be extremely helpful for treatment-resistant depression, it is absolutely imperative that these clients use it under medical supervision. This is because, in the wrong dosage, it may cause suicidality. In one clinical trial,13 some participants with TRD “experienced a ‘serious adverse event,’ such as suicidal behavior, intentional self-injury or suicidal ideation.” This may have been due to an incorrect dosage or inadequate medical supervision, either during or after the experience. Whatever the reason, this data illustrates that there is still much to learn about this treatment. If you decide to try it, a private rehab center that offers psilocybin treatment will ensure you do so under the supervision of an experienced clinical team and a clear plan for aftercare.

Unlike most, or possibly all, other pharmaceutical treatments, psychedelics are strongly influenced by the client’s intention. “Positive expectancy”18—or, the expectation that the treatment will help—has been shown to have an impact on psilocybin’s effectiveness. If you go into an experience with acute anxiety, trepidation, or a belief that it will go poorly, you’ll probably be proven right. On the other hand, if you’re in a positive or hopeful state, you may experience much greater benefits. It’s important to plan these experiences carefully, but also stay mindful of your own feelings in the moment as you approach treatment. If you’ve planned extremely well, and then you feel poorly when the day arrives, it’s best to postpone if at all possible.

Is Psilocybin Right for You?

Psilocybin, even more than other treatments, is an extremely personal experience. Not everyone is emotionally prepared to dive that deeply into their own subconscious. And even if it feels right for you, it may not be appropriate on any given day. The act of planning this treatment can be a powerful exercise in mindfulness, even before the substance is administered.

Under the right circumstances, though, clients find psilocybin to be immensely positive. And as we amass more data, doctors will likely find ways to make it even safer. If you decide to try this treatment, understand that there is still much to learn. In this early stage of research, it should absolutely not be your only form of treatment for any diagnosis. But with the right setting, dosage, and therapeutic team, it may be extremely helpful.

Discover Rehabs That Treat Depression

Latest studies show that psilocybin is a promising treatment for depression, however this form of therapy isn’t widely available yet. At the same time, there are several other forms of therapies and treatment programs for depression out there. To learn more about your options, browse our collection of rehabs that specialize in depression treatment.

Frequently Asked Questions About Treating Depression With Psilocybin

What is psilocybin and how does it work in depression treatment?

Psilocybin is a naturally occurring psychedelic compound found in certain mushrooms. It interacts with serotonin receptors and their subtypes in the brain, leading to altered states of consciousness. Because of its impact on serotonin, it has potential therapeutic effects in depression and anxiety treatment.

What are the potential benefits of psilocybin in treating depression?

Psilocybin-assisted therapy has shown promise in improving mood, reducing depressive symptoms, increasing emotional openness, and promoting long-term positive changes in individuals with treatment-resistant depression.

Is psilocybin treatment for depression safe and legal?

Psilocybin is a Schedule I controlled substance in many countries, but it is being researched for therapeutic purposes. Psilocybin-assisted therapy is conducted in a controlled and supervised setting to ensure safety. Ongoing studies aim to assess its efficacy and safety profiles.

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Natural Wellness at Mexico Rehabs

During rehab, you’ll have the opportunity to take a step back from unhealthy habits. By creating space between yourself and your daily life, you can gain a new perspective. If you go to rehab in Mexico, that distance can be both physical and philosophical.

Many of Mexico’s luxury rehab centers take a holistic approach to healing. During your stay, you won’t just attend talk therapy; you might also change your eating habits, get physical exercise, or take up meditation. These programs may even offer medical treatments that aren’t available in most areas, such as ibogaine therapy.

When you consider the area’s vibrant culture and beautiful landscape, it’s easy to see why so many facilities emphasize healthy lifestyles. Luxury rehabs in Mexico take full advantage of these resources, offering clients the opportunity to explore the countryside during treatment.

Mexico Is More Than a Tropical Paradise

Many people think of Mexico as having a tropical climate.1 And indeed, more than half of the country is located south of the Tropic of Cancer. As a result, the weather in that area is temperate, varying little from one season to the next. However, depending on your elevation, the average daily temperature may be as high as 77 degrees Fahrenheit (25 degrees Celsius) or as low as 59 degrees Fahrenheit (15 degrees Celsius). North of the tropics, in regions like Baja California and the Sonoran desert, temperatures vary more widely throughout the year.

The country has some highly populous areas, like Mexico City, as well as many rural destinations. While some rehab centers are close to downtown districts—and may even take their clients on shopping trips—most are located in remote areas. This gives clients the opportunity to retreat from the hustle and bustle of urban life, and to commune with the natural world. In these programs, clients are often invited to explore the surrounding landscape, using experiential therapy as one mode of healing.

Experiential Therapies in Mexico Rehabs

Mexico is “one of the world’s more biologically diverse countries”,2 encompassing vast deserts, tropical rainforests, mangrove swamps, and alpine ecosystems.” Its beautiful beaches are also popular travel destinations. In some programs, clients can visit these areas during treatment. While these experiences can be fun, they’re also important components of healing. Experiential therapy is known to have many benefits for people in recovery from substance use disorders.

Sports by the Sea

Depending on which program you attend, you may have access to a wide variety of seaside activities. At Twilight Recovery Center, for example, clients may go scuba diving. These experiences allow you to commune with nature while also getting exercise.

Mexico scuba diving
Mexico offers a variety of seaside activities, like snorkeling and scuba diving.

Substantial research supports the idea that exercise can benefit people in recovery from substance use disorders.3 While they may be physically challenging, these experiences are both safe and closely supervised. They also give you the opportunity to develop or improve a skill, build relationships with your cohort, and observe your own emotional responses in a new context.

For people who prefer not to engage in sports, there are many other ways to enjoy the beach. In some seasons, you may be able to go whale watching or witness the release of sea turtles. Some rehabs also take clients on fishing trips and boating tours. These experiences may be more accessible for some clients, depending on their physical condition.

Equine Therapy

Some Mexican rehab facilities, like Hacienda del Lago, invite clients to go horseback riding, or simply spend time among horses. A growing body of research has found that equine therapy has great benefits for people in recovery from substance use.4

This experience is “more than just a break from treatment.” It also lets you practice building relationships, without the pressure of connecting with other people. Many clients report that horses mirror their own behavior and emotions. This has important implications for people who are learning, or relearning, how to regulate difficult feelings in new contexts.

Hiking

Many rehab programs take their clients on regular excursions to visit naturally beautiful areas. Clients at Rē Precision Health, for example, may get the chance to explore waterfalls, beaches, and even the jungle.

Practitioners at this facility strongly believe in the healing effects of nature. This view is supported by a growing body of research, which demonstrates “significant associations between nature experiences and positive mental health outcomes”5 Like so many of the therapies available at Mexico’s rehabs, this holistic experience allows you to engage both body and mind.

Ibogaine Therapy in Mexico

In addition to experiential therapies, some rehabs in Mexico offer access to certain pharmaceutical treatments that are hard to find in other countries. In particular, ibogaine is an increasingly popular treatment for several mental health concerns, including substance use disorders.

clear sky recovery pool
Clear Sky Recovery in Cancun, Mexico.

This natural medicine, extracted from the African iboga shrub, “has great potential,” according to experts. “Small studies have suggested it can dramatically reduce drug cravings and withdrawal symptoms.”6 However, ibogaine is difficult to access in the United States. If you’re located in the U.S., and you’d like to use it to aid with recovery, you may have to travel abroad.

It’s especially easy to find ibogaine treatment in Mexico. Some rehab centers, like Iboga Quest, specialize in this type of therapy. Although the program is centered around ibogaine, it is offered in combination with well-known Western techniques. During the treatment process, clients are closely monitored by a medical team throughout the experience.

Clear Sky Recovery is another program offering this type of treatment. According to their team, the experience of ibogaine treatment may last for up to 24 hours, or sometimes even longer. During that time, the client enters a dreamlike state, and has the opportunity to relive core memories and gain new insight into their own psyche.

Ibogaine can be extremely effective for many clients. However, it “is not a miracle cure,” cautions Álvaro de Ferranti, Founder of Tabula Rasa Retreat in Portugal. “It is, however, an incredibly effective detox tool and an addiction interrupter.”

“The beauty of ibogaine is that it allows someone to resolve issues deep down.”

– Álvaro de Ferranti, Founder of Tabula Rasa Retreat

With or without the use of ibogaine, many treatment programs take a similarly holistic approach to wellness. For example, you might talk about core memories in therapy, or access a dreamlike state through mindful meditation. There are countless natural ways to delve deep into your emotional experience. And these techniques are easy to find in Mexico’s rehab centers.

Holistic Treatment in Mexico

Holistic recovery may incorporate a variety of therapeutic techniques. Sometimes these methods are offered alongside evidence-based strategies. Some 12-Step programs even utilize holistic strategies alongside groups like A.A. and N.A. In other rehab centers, clients only engage in these natural methods instead of using more clinical strategies.

Natural Detox

Narconon Latin America, which is founded on the principles of Scientology, guides clients through an entirely drug-free detox process. This may be a good fit for clients who want to engage in total abstinence as part of recovery.

However, it’s important to note that this type of detox may not be physically safe for all clients. Make sure you check with your doctor before undergoing this type of treatment, to make sure it doesn’t represent a significant risk. Some clients may need to use prescription medications in order to stay healthy during detox and recovery.

If this detox style isn’t right for you, there are many other ways to use natural and holistic methods during recovery.

Mindfulness Practices

Several rehabs in Mexico teach mindfulness techniques, such as yoga, breathwork, and meditation. These activities may be integrated into your daily schedule, or they may be electives.

yoga mindfulness
Mindfulness practices, such as yoga, are often incorporated into treatment programs at rehabs in Mexico.

Mindfulness empowers you to stay present in each moment. As this technique grows increasingly popular, some are starting to dismiss it as being too trendy. However, mindfulness is an ancient practice whose efficacy is supported by modern science.7

These skills are known to improve attention, compassion, and resilience to stress. They are especially useful for people in recovery. Connecting to your current—and ever-changing—emotional state may help you consistently make healthy choices. This skill may become a lifelong practice that you continue long after completing in-patient treatment.

Healthy Eating

Daily habits have a huge impact on your mental health. With that in mind, several Mexico rehabs focus on physical health and good nutrition. Some locations, like Moffitt Wellness Retreat, serve gourmet meals and natural, fresh-pressed juices, inviting you to enjoy the healthy pleasures life has to offer.

It’s extremely common for people with substance use disorders to experience nutrient deficiencies. However, “there is no special nutritional assessment or guidance” for people in recovery. To support your unique dietary needs, your team may help you develop a customized nutrition program,8 which will dictate your diet during residential treatment.

Life-Long Aftercare

Oceanica Treatment Center, in Sinaloa, Mexico, is a resort-like rehab that offers highly personalized treatment. Their program is tailored to meet your changing needs during every step of the recovery process—even after you finish inpatient treatment.

Most luxury rehabs help clients plan for aftercare, and some offer even more extensive aftercare services. Oceanica Treatment Center goes above and beyond. “​​Once clients finish the residential phase, weekly monitoring is provided via telephone. Monitoring includes contact with family members (if the client allows) and provides support during the recovery process. The aftercare program also has weekly therapeutic groups that are in person or virtual. This aftercare process lasts 6 months, but Oceanica maintains relationships with the graduates for a lifetime through virtual communication or in-person alumni get-togethers.”

Recovery is a lifelong process, and like any healing journey, it comes with ups and downs. This approach ensures that you’ll always have the support you need, even after you leave residential rehab.

Traveling to Rehab in Mexico

If you’ll be traveling internationally to attend rehab in Mexico, make sure you talk to your rehab program’s admissions team before planning the details of your trip. Regulations vary from country to country, and may also be based on your country of citizenship. Since 2020, travelers have been subject to even greater restrictions, which may continue to change significantly over short periods of time. It’s important to research local and federal regulations in advance. Note that different airlines also have their own safety protocols; make sure to choose one that meets your specific needs.

If you’re a U.S. citizen flying into Mexico, you’ll need a valid U.S. passport book; passport cards may not be accepted. If you’re traveling by car, you may need a special vehicle permit. This is subject to change depending on where you cross the border. You’ll also need to obtain a tourist visa if you plan to stay in the country for more than 180 days. Although this exceeds the length of most rehab programs, it may impact your plans for aftercare.

For people who are just beginning detox and recovery, it’s important to streamline the travel process as much as possible. In order to minimize these logistics, most rehab facilities offer transportation to and from the nearest airport. It’s best to work with the staff at your rehab facility to plan the details of your trip. Remember that even before you arrive at rehab, you’re allowed to ask for the help you need.

Mexico’s Rehabs Make Recovery Meaningful

The act of traveling to rehab empowers clients to gain a new perspective on their daily lives. Physical distance not only separates you from potentially difficult situations; it can also give you much-needed emotional space. In that space, you can learn more about your own needs, goals, and values in a brand-new context.

In Mexico, residential treatment will also teach you how to live well, naturally. Your time there may focus less on medical treatment and more on the skills you need to navigate the world without substance use. These techniques are intended to be sustainable, accessible, and tailored to support a lifestyle you love.

As powerful as holistic healing can be, it’s not the right strategy for everyone. Some clients may need more medical support during detox and recovery. Others may benefit from highly clinical therapies, such as cognitive behavioral therapy (CBT). If you have reason to think you’d benefit from this type of approach, holistic therapy may be ineffective, or even counterproductive.

You have nothing to prove by choosing one rehab facility over another. This is a time to focus on your own mental health, above almost anything else. No matter how much a certain philosophy appeals to you on paper, it may or may not actually be the appropriate way for you to approach healing. If natural wellness sounds like the best possible way for you to begin recovery, a rehab in Mexico is likely to be a good fit.

Frequently Asked Questions About Rehab In Mexico

What are the benefits of luxury rehab in Mexico?

Luxury rehabs in Mexico offer several benefits: 

• Personalized treatment plans 
• Unique therapies including ibogaine therapy
• Experiential therapies
• World-class facilities
• Serene environments
• Experienced medical staff

How much does luxury rehab in Mexico cost?

The cost of luxury rehab in Mexico depends on factors such as treatment duration, level of treatment, amenities, and more. Some rehabs cost under $10,000 for a 30-day program. A majority of Mexico luxury rehabs cost between $10,000 to $25,000. These offer upscale amenities, luxurious accommodations, and highly specialized treatment.

What types of addiction treatment are available in luxury rehabs in Mexico?

Addiction treatment in Mexico covers the full spectrum of care. You can find detoxification programs, residential rehabs, outpatient programs, intensive outpatient programs (IOPs), and sober living. Many programs offer a range of treatments, including individual and group therapy, holistic approaches, complementary therapies like equine therapy, 12-step programs, family counseling, and aftercare planning to promote long-term recovery.

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Finding Help for Treatment-Resistant Depression

Treatment-resistant depression (TRD) has the same symptoms as depression, but with a more complex recovery process. Because of its effect on energy levels, depression can interfere with your capacity to seek help. This makes TRD especially daunting for many people. It takes a great deal of determination to try new treatments, with the knowledge that just finding the right modality may take some time. As difficult as this is, it’s important to stay focused on the goal of getting well. 

Whatever treatment you’re currently trying, you can always continue to learn about this condition. Knowledge is power. The more you know about treatment-resistant depression, the better equipped you’ll be to manage your symptoms and get the depression help you need. 

Lifestyle Changes and Behavioral Health Treatments for TRD

Treatment-resistant depression1 is defined as depression with symptoms that are not alleviated after trying two or more treatment options (medications) for at least six weeks each. Despite the myriad medical and behavioral options for treating depression, many people still struggle to find an effective treatment. One-third of people with major depression have TRD.2 

If you think you may have treatment-resistant depression, you’re likely already familiar with the symptoms of major depression.3 While these criteria are well understood, research is beginning to explore some of their underlying causes. 

Most people understand depression to be related to chemical factors in the brain. There are a number of environmental factors that may contribute to depression4—and it’s not just physical health. Depression has recently been associated with more frequent use of screens (cell phones, computers, etc.), and a lack of access to green space. High levels of air and noise pollution may also exacerbate symptoms. On the other hand, activities that guard against depression include confiding in other people, being part of a sports club or gym, and strangely enough, eating cereal. 

These protective factors paint a clear picture: eating cereal with friends at the gym might be a valid treatment for treatment-resistant depression. In all seriousness, though, most of the activities that diminish the chances of depression include social support. That support doesn’t have to come from friends; it can also come from a one-on-one therapist, a psychiatrist, or a support group. The simple act of reaching out for help can have an immensely positive impact on TRD.

tabula rasa depression rehab
Tabula Rasa Retreat in the Alentejo Region of Portugal uses ibogaine therapy to induce a profound psychedelic state that many clients find helps them to make breakthroughs in healing their depression.

Alternative Therapies for Treatment-Resistant Depression

Holistic and alternative modalities are an increasingly popular way to treat mental health conditions. People with treatment-resistant depression might be particularly interested in these types of therapy. If traditional interventions—like SSRIs, talk therapy, and exercise—haven’t worked, you may be ready to try a radically different strategy. 

Many of these depression treatments , like psychedelic-assisted therapies,5 are just starting to gain traction. However, they are not new. This class of medications was studied extensively from 1943-1970. The political shift of the 1970’s pushed researchers away from the subject, but now, public perception of psychedelics is starting to change. More effective treatments for TRD are very likely on the horizon. 

In this new era, the stigma once associated with alternative therapy is dissipating. It’s an exciting time for anyone who wants to find new ways of treating mental health. That’s true for both clinicians and people dealing with their own diagnoses. Living with treatment-resistant depression might not be straightforward, but the number of safe and readily available treatments is steadily growing.

Ketamine Therapy for Depression

Ketamine is a psychedelic dissociative that can be helpful in treating depression,6 including TRD, and PTSD. It is administered in a supervised setting, rather than being prescribed for daily use. Ketamine IV treatments may be conducted individually or with small groups, and are always closely monitored by a medical team. 

Ketamine therapy is intended to give you space to step back from your emotional experience, and to process your feelings from a more objective point of view. This perspective can be especially helpful in treating depression; simply taking space from your feelings can result in the immediate relief of some symptoms. Clients enter a trance state, during which they gain greater insight into their lives, often returning to full consciousness with renewed energy and a clear sense of how to move forward. The pharmaceutical aspect of ketamine therapy is often, but not always, combined with talk therapy either before or after the treatment itself. This invites clients to process the experience and set intentions for the future. 

Ibogaine Treatment for Depression and Addiction

Ibogaine is a psychedelic that can be used to treat depression and addiction. According to MAPS, it is “a psychoactive alkaloid naturally occurring in the West African shrub iboga. While ibogaine is a mild stimulant in small doses, in larger doses it induces a profound psychedelic state. Historically, it has been used in healing ceremonies and initiations by members of the Bwiti religion in various parts of West Africa.” Modern-day clinicians are finding that clients with treatment-resistant depression also benefit from ibogaine therapy.7

Like ketamine, ibogaine is administered in a protected, controlled environment. Although more research is needed into this form of therapy, ibogaine shows promising results in observational studies.8 Thanks to these positive outcomes, this treatment is becoming more readily available in a number of settings, including rehab facilities. 

For many clients, ibogaine therapy is a transcendent, even spiritual experience. By revisiting past experiences, they are able to reconnect with their higher selves. Álvaro de Ferranti, Founder of Tabula Rasa, explains that this treatment “heals the pain by helping the user deal with deep-seated traumas and emotional baggage. It helps them open themselves up to new possibilities, to let self-love back in, and to simply allow them to get back to self again.”

mountain springs recovery
Mountain Springs Recovery in Monument, Colorado treats depression using an evidence-based approach.

Combined Approaches to TRD Treatment

Pharmaceutical methods are just one way of treating resistant depression.9 Evidence supports the theory that a combined approach, including multiple modalities at once, is the most effective way to affect change. In order to achieve this, you may need to assemble a team of healthcare providers with different specialties. 

Treatment-resistant depression is a mental health condition, but it can also impact your physical health, your relationships, and every other area of your life. Because of this, you can likely benefit from working with not just a psychiatrist and talk therapist, but also a personal trainer, massage therapist, or even an acupuncturist. If you want to kickstart the healing process with intensive treatment, you may want to consider inpatient treatment, or an IOP. As you try various modalities, remember that there’s no one right or simple answer. You might need to experiment with a few different combinations before finding what works best for you.

How to Know When to Try a New Treatment

When you begin treating any condition, whether it’s mental or physical, it’s important to track your symptoms carefully. For TRD, you can do this by journaling, using a mood tracker, or even making a spreadsheet to track how different behaviors affect your emotional state. Working with healthcare providers can also be extremely helpful in this process. A therapist will be able to refer to their notes, and provide objective insight into your progress over time. 

If you decide to try pharmaceutical treatment for treatment-resistant depression,10 it’s absolutely essential that you follow your prescriber’s directions. Brain chemistry changes slowly, and it can be hard to know whether a new medication is working unless you give it adequate time to take effect. Research suggests that it takes at least 4 to 6 weeks on a new treatment before you start seeing results.  That being said, everyone’s brain chemistry is different, and your experience may be different from this. Make sure to work closely with your provider to manage any side effects, and get their advice before stopping a medication. 

When you’re working with an expert in any field, whether they’re a therapist or an interior decorator, it can take time to find the right person for you. If you’ve been seeing a therapist for some time without noticeable results, don’t be afraid to look for a new provider. That being said, don’t jump ship just because it doesn’t feel good. The work of therapy may not be easy or fun; the question is whether it’s helping you make positive, sustainable changes in the rest of your life. 

Because depression often has environmental causes, it can also be helpful to see how your mood changes based on external factors. For example, do you feel worse in rainy weather, or when you don’t have time to see friends? In some cases, you can make behavioral changes to manage these symptoms, such as investing in a sun lamp or rearranging your schedule. However, you’re unlikely to stop encountering common triggers. If these external circumstances have less of an effect on your mood as you continue treatment, it’s a sign that you’re on the right track. 

As Rowland Tweedie, Health and Fitness Manager of Paracelsus Recovery, sees it, “People are 360 degrees. All of us, we’ve got many aspects of our life: our health, our mental state, our physical state.” While the road to recovery may not be simple or straightforward, this process will undoubtedly teach you a great deal about yourself. 

Healing From TRD is an Opportunity

As painful as treatment-resistant depression can be, it can also be an opportunity. If you’re able to cultivate an attitude of curiosity about yourself and your healing journey, the process may be far less arduous. 

When you try several different types of therapy, you’ll learn about yourself from every angle. People are complex, powerful, and multifaceted. That includes you. As you get to know yourself better, you may find that recovery is a creative act. For people with TRD, it means more than finding the right pill. Instead, this is the process of building a better and more fulfilling life. 

To learn more about different TRD therapies, you can connect with an inpatient rehab facility that treats depression.

Frequently Asked Questions About Treatment-Resistant Depression

How do I know when to try a new treatment for treatment-resistant depression (TRD)?

To determine when to try a new treatment for treatment-resistant depression (TRD), you can use tools like journaling, mood trackers, or spreadsheets to track how you feel day to day. Working closely with your therapist and other treatment providers can provide valuable insights into your progress and guide decisions about trying new approaches.

What alternative therapies are available for treatment-resistant depression?

Alternative therapies, including psychedelic-assisted therapies, are emerging as potential treatments for treatment-resistant depression (TRD). These therapies offer new possibilities for people whose depression hasn’t responded to traditional interventions.

How can combined approaches be effective in treating treatment-resistant depression (TRD)?

Combining multiple therapies and working with a team of healthcare providers with different specialties can be the most effective approach in treating treatment-resistant depression. This comprehensive approach addresses the multifaceted impact of TRD and can lead to better outcomes.

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Treating Depression With Ketamine and Psychedelics

spiral staircase marble steps brass banister photo cred: ludde lorentz

Both ketamine and psychedelics have emerged as popular therapeutic methods in recent years for those who have been resistant to other forms of depression treatment. While many medical professionals and people who have undergone these treatments attest to their benefits, there are still legitimate concerns being expressed about the potential risks associated with their use.

]We take a look at some factors to consider, and the science behind this approach.

How Ketamine Is Used to Treat Depression

Ketamine’s most common medical use is as an anesthetic and a sedative. But it can also be used as a fast-acting antidepressant, usually in the form of a nasal mist or IV infusion performed under medical supervision. Studies have shown that, starting within 4 hours of receiving a dose, ketamine relieved the symptoms of depression for approximately one week at a time.1 Research further suggests that ketamine causes new connections to form in brain. Its fast-acting effectiveness and impacts on neuroplasticity have led clinicians like Gerard Sanacora, Psychiatry Specialist at Yale Medicine, to speculate on its increased use in medical research.

“It’s quite possible that we will see more medical institutions offering ketamine as a treatment,”2 says Sanacora. “And the FDA recently approved the use of esketamine, which is derived from ketamine. These are all very exciting prospects.”

Is Ketamine Safe?

Currently, ketamine is only approved by the FDA as an anesthetic and pain reliever,3 not as a depression treatment. This is largely due to the fact the long-term impacts of ketamine are mostly unknown. Since it’s also used recreationally for its narcotic properties, addiction risk is a major concern. Too much ketamine can have adverse effects like dissociation, hallucinations and paranoia (known as a “K-hole”).4 While ketamine administered in the proper doses under professional supervision is considered safe, these concerns prevent it from becoming more mainstream.

How Psychedelics Are Used to Treat Depression

Psychedelics have a different way of treating depression. Research shows that hallucinogens like psilocybin (found in psychedelic mushrooms), LSD and ayahuasca can potentially relieve the depression symptoms after just a single dose. Successful psychedelic treatments can help people gain clarity about problems they’re experiencing, giving them the opportunity to access their subconscious and process past traumas they had previously suppressed. According to recent studies, psychedelics enhance people’s feelings of connectedness with others,5 their spirituality and their sense of meaning. Some studies suggest that these substances open pathways in the brain—hence the notion that psychedelics expand your mind. While this sounds promising, the science on how these drugs work to treat depression is still being studied.

Watch this TED Talk by Mark Haden, Adjunct Professor at the University of British Columbia School of Population and Public Health, to learn more about psychedelics:

Are Psychedelics Safe?

Psychedelics also pose their own set of risks. Although they’re not generally considered to carry high addiction risk, there can be unpredictable short-term effects of psychedelics.6 Not least of these is a “bad trip,” which can include symptoms like extreme paranoia, anxiety, and loss of psychological control. While these symptoms usually subside within a relatively short period of time, they can lead users to place themselves in dangerous situations. Generally speaking, however, when intentionally therapeutic doses of ketamine or psychedelics are administered by professionals in safe environments, the risks to your safety are quite low.

Finding the Right Rehab for Depression

If you’ve tried different treatment methods for depression and find yourself still struggling with this debilitating disorder, know that there is an abundance of treatment options out there, and some may work better for you than others. While ketamine or psychedelics may not be for you, a variety of other program offerings might be.

Visit our collection of luxury rehabs specializing in depression treatment to explore some of the world’s best centers today.

Frequently Asked Questions

How can ketamine and psychedelics be used to treat depression?

Ketamine and psychedelics treat depression by influencing the brain’s chemical pathways, promoting new thought patterns and behavior. They can provide rapid relief for symptoms of depression, and may be particularly useful for people who haven’t found success with other treatments.

What is the difference between ketamine and traditional antidepressants?

Unlike traditional antidepressants which can take several weeks to start working, ketamine can provide relief from depression symptoms within hours. Ketamine targets different neurotransmitter systems in the brain compared to other antidepressants, making it a valuable treatment option for people who haven’t responded to other medications. Additionally, helps repair damaged neural pathways, leading to longer-lasting effects.

What’s the process for ketamine or psychedelic therapy for depression at a residential rehab center?

In residential rehab, you’ll undergo ketamine or psychedelic therapy under the guidance of qualified professionals. Patients are carefully screened to ensure that they’re appropriate candidates for these treatments. After an initial consultation, your care team will develop a personalized treatment plan, and you’ll receive the medication in a comfortable, private setting. The treatment is closely monitored to ensure safety and efficacy, and you may receive ongoing therapy and support to promote long-term recovery.